In vitro activity of ceftizoxime and ceftazidime in presence of essential and trace elements

The research work comprises of the study of the changes in antimicrobial activity of ceftizoxime and ceftazidime after interaction with essential and trace elements. The minimum inhibitory concentration (MIC) was observed and thereafter compared with the standard MIC's of the respective drug by agar dilution method against both Gram positive and Gram-negative organisms so as to evaluate changes in antimicrobiological activity of the standard cephalosporins after metal interactions. It was observed that these metal elements that are essential for our body, either present within the body or coadminstered with vitamins markedly influence the MIC's of antibiotics by producing synergism or antagonism.