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Antimicrobial activity of Penicillins in common paediatric infections

Masroor Ahmed1, Baqir S Naqvi, Muhammad Harris Shoaib

  • 1Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi.

Pakistan Journal of Pharmaceutical Sciences
|January 18, 2006
PubMed

Insights

Pediatric bacterial infections are rising in developing nations, with antimicrobial resistance posing a significant challenge. Surveillance programs are crucial for monitoring antibiotic resistance in pediatric bacterial infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Pediatric bacterial infections are increasing in developing countries.
  • Antimicrobial resistance is a critical challenge in treating these infections.
  • Surveillance programs are essential for controlling antibiotic resistance.

Purpose of the Study:

  • To assess antibiotic resistance patterns in bacterial isolates from pediatric wards.
  • To identify effective antimicrobial agents for treating pediatric bacterial infections.

Main Methods:

  • Bacterial isolates were collected from pediatric wards of various hospitals.
  • Antimicrobial susceptibility testing was performed using selected antibiotics.
  • Minimum Inhibitory Concentrations (MICs) were determined.

Main Results:

  • Isolates exhibited high resistance to most tested antibiotics, with elevated MICs.
  • Amoxicillin and clavulanic acid showed over 90% susceptibility against Staphylococcus aureus.
  • Cloxacillin, ampicillin, and amoxicillin alone demonstrated moderate activity against Staphylococcus aureus and Escherichia coli.

Conclusions:

  • Significant antibiotic resistance is present in pediatric bacterial infections.
  • Amoxicillin/clavulanic acid is a potentially effective agent against Staphylococcus aureus.
  • Continued surveillance is vital for managing antimicrobial resistance in pediatric populations.

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