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Bioactivity evaluation of Bergenia ciliata
Mazharul Islam1, Iqbal Azhar, Khan Usmanghani
1Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi.
Pakistan Journal of Pharmaceutical Sciences
|January 18, 2006
Summary
Bergenia ciliata exhibits significant hypoglycemic activity, reducing blood glucose levels by 40-70% in experimental diabetes models. However, toxicological studies revealed severe systemic and intracutaneous toxicity, indicating potential risks.
Area of Science:
- Pharmacology
- Ethnobotany
- Toxicology
Background:
- Bergenia ciliata is a medicinal herb traditionally used for its hypoglycemic properties.
- Folklore medicine utilizes Bergenia ciliata to manage symptoms associated with diabetes mellitus.
Purpose of the Study:
- To investigate the bioactivity and toxicological profile of Bergenia ciliata extracts.
- To scientifically validate the traditional use of Bergenia ciliata for managing hyperglycemia.
Main Methods:
- Bioactivity assays were conducted on various Bergenia ciliata extracts.
- Hypoglycemic activity was assessed in Streptozotocin (STZ)-induced diabetic rats.
- Toxicological evaluations included acute systemic, intracutaneous toxicity, and hemolysis tests.
Main Results:
- Most Bergenia ciliata extracts demonstrated significant hypoglycemic activity (40-70% reduction in blood glucose).
- Toxicological studies indicated severe acute systemic and intracutaneous toxicity, with symptoms like erythema, edema, breathing difficulties, and bloody diarrhea.
- The hemolysis test showed minimal activity for the extracts.
Conclusions:
- Bergenia ciliata possesses notable hypoglycemic effects but also exhibits significant toxicity.
- Further research is needed to identify the specific toxins and elucidate the mechanism of action.
- The findings suggest cautious use of Bergenia ciliata due to its toxicity profile.