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Synovial sarcoma.

R E Gerner, G E Moore

    Annals of Surgery
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Synovial sarcoma has a poor five-year survival rate of 36%. Wide excision, potentially including amputation, is recommended over local excision to reduce recurrence, as node dissections are ineffective. Adriamycin shows promise for treatment.

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    Area of Science:

    • Orthopedic Oncology
    • Surgical Oncology
    • Medical Oncology

    Background:

    • Synovial sarcoma is a rare soft tissue sarcoma.
    • Local excision is associated with high recurrence rates.
    • Current treatment strategies require optimization for improved patient outcomes.

    Purpose of the Study:

    • To evaluate the treatment outcomes and survival rates for synovial sarcoma.
    • To determine the optimal surgical approach for managing localized disease.
    • To assess the efficacy of adjuvant therapies, including chemotherapy and radiation.

    Main Methods:

    • Retrospective analysis of 34 patients diagnosed with synovial sarcoma.
    • Comparison of outcomes based on surgical technique (local vs. wide excision).

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  • Assessment of the impact of adjuvant therapies on survival and recurrence.

    • Main Results:

    • The five-year survival rate for synovial sarcoma was 36%.
    • Local excision resulted in a high rate of local recurrence.
    • Wide excision, sometimes requiring amputation, is the preferred surgical treatment.
    • Prophylactic and therapeutic lymph node dissections did not improve survival.
    • Adriamycin demonstrated a tumoricidal effect with clinically significant responses in several patients.

    Conclusions:

    • Wide surgical excision is the treatment of choice for synovial sarcoma to minimize local recurrence.
    • Lymph node dissection is not effective in improving survival for this disease.
    • Adriamycin shows potential as a chemotherapeutic agent for synovial sarcoma, warranting further investigation.