Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective decrease of Na+/k+ -ATPase activity in the brain of hypothyroid rats.

Jorge Pacheco-Rosado1, G Arias-Citalán, R Ortiz-Butrón

  • 1Depto. de Fisiología Mauricio Russek, Escuela Nacional de Ciencias Biológicas, I.P.N., Carpio y Plan de Ayala, México, D.F., 11340. Jpacheco@encb.ipn.mx

Proceedings of the Western Pharmacology Society
|January 19, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anxiety-like behavior in chemical window kindling-elicited seizures in male Wistar rats.

Epilepsy research·2026
Same author

Mitotic Activity, Cell Survival, and Neuronal Differentiation in the Hilus of the Dentate Gyrus Under Physiological and Hypothyroid Conditions in Adult Wistar Rats.

Cells·2025
Same author

Is the acquired hypothyroidism a risk factor for developing psychiatric disorders?

Frontiers in psychiatry·2024
Same author

Neuropsychological Alterations in Patients with Congenital Hypothyroidism Treated with Levothyroxine: Linked Factors and Thyroid Hormone Hyposensitivity.

Journal of clinical medicine·2022
Same author

Quantitative characterization of proliferative cells subpopulations in the hilus of the hippocampus of adult Wistar rats: an integrative study.

Journal of molecular histology·2020
Same author

Cardiovascular Responses to 5-hydroxytryptamine in Methimazole-induced Hypothyroid Pithed Rats.

Archives of medical research·2020

Mild hypothyroidism in rats significantly reduced Na+/K+-ATPase enzyme activity in key brain regions. Thyroid hormone (T3) replacement therapy largely restored enzyme function, except in the amygdala.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Biochemistry

Background:

  • The Na+/K+-ATPase is a crucial ion pump maintaining cellular homeostasis and neuronal function.
  • Thyroid hormones play a vital role in brain development and function.
  • Alterations in thyroid hormone levels can impact neurological processes.

Purpose of the Study:

  • To investigate the effect of mild hypothyroidism on Na+/K+-ATPase activity in specific rat brain regions.
  • To determine if thyroid hormone (T3) replacement can reverse hypothyroidism-induced changes in enzyme activity.

Main Methods:

  • Male Wistar rats were divided into control, hypothyroid (methimazole-treated), and hormone-replaced (methimazole + T3) groups.
  • Na+/K+-ATPase activity was measured in cortex, amygdala, hippocampus, and cerebellum using inorganic phosphate quantification.

Related Experiment Videos

  • Enzyme activity was assessed after four weeks of treatment.

    • Main Results:

    • Hypothyroidism led to a significant decrease in Na+/K+-ATPase activity in the cortex, amygdala, and hippocampus compared to controls.
    • No significant change in enzyme activity was observed in the cerebellum of hypothyroid rats.
    • T3 co-administration normalized Na+/K+-ATPase activity in most regions, with the exception of the amygdala.

    Conclusions:

    • Mild hypothyroidism reduces Na+/K+-ATPase activity in brain regions associated with seizure onset.
    • Thyroid hormone replacement therapy can mitigate these enzyme activity deficits.
    • The amygdala may exhibit unique sensitivity to thyroid hormone levels regarding Na+/K+-ATPase activity.