Related Experiment Video

Updated: Aug 8, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Thrombus size is associated with etiology of deep venous thrombosis--a cross-sectional study

Niksa Vucić1, Tihana Magdić, Anton Krnić

  • 1Department of Internal Medicine, General Hospital "Sveti Duh", Zagreb, Croatia.

Collegium Antropologicum
|January 19, 2006
PubMed

Insights

Malignant diseases significantly increase deep vein thrombosis (DVT) clot size, with cancer patients exhibiting the largest thrombi. Understanding DVT risk factors is crucial for assessing clot severity.

Area of Science:

  • Vascular Medicine
  • Hematology
  • Thrombosis Research

Background:

  • Deep vein thrombosis (DVT) is a significant vascular condition.
  • Identifying risk factors associated with DVT severity is clinically important.

Purpose of the Study:

  • To investigate the relationship between various risk factors and thrombus size in lower extremity deep vein thrombosis.
  • To determine which risk factors are most strongly associated with larger DVT clot burden.

Main Methods:

  • Patients diagnosed with DVT had their thrombus size scored using the International Consensus Committee for venous disease classification.
  • Predominant DVT risk factors were identified for each patient.
  • Statistical analysis was performed to correlate risk factors with thrombus scores.

Main Results:

  • The average thrombus score was 6. Patients with malignancy had the largest average thrombus score (8.5), significantly higher than other risk groups.
  • Age showed a slight positive correlation with thrombus size (r = 0.19, p = 0.046).
  • No significant correlation was found between symptom onset to diagnosis time and thrombus score (r = -0.08, p = 0.38). Gender had no significant impact.

Conclusions:

  • The etiology of deep vein thrombosis, particularly the presence of malignant diseases, is the primary determinant of venous thrombus size.
  • Malignancy represents a critical risk factor associated with the most extensive DVT.
  • Further research into the mechanisms linking cancer and DVT severity is warranted.

More Related Videos

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography06:44

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography

Published on: April 13, 2018

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis08:50

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Published on: January 9, 2026

Related Concept Videos

Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...