Related Experiment Video

Updated: Sep 14, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Systemic lupus erythematosus

J M Jones, A J Martinez, V V Joshi

    Archives of Pathology
    |March 1, 1975
    PubMed

    Insights

    Systemic lupus erythematosus (SLE) may involve paramyxovirus-like structures and defective immunity. A child with SLE showed these findings, along with herpes simplex virus particles and thymic dysplasia, suggesting potential viral links in autoimmune disease.

    Area of Science:

    • Immunology
    • Virology
    • Pathology

    Background:

    • Systemic lupus erythematosus (SLE) investigations reveal paramyxovirus-like nucleocapsids in renal endothelial cells.
    • SLE is associated with increasing evidence of defective cell-mediated immunity.
    • Previous studies have faced challenges in definitively identifying these structures as viruses.

    Purpose of the Study:

    • To investigate the presence of viral-like structures and immune defects in a pediatric case of SLE.
    • To correlate clinical findings of immune deficiency with postmortem pathological observations.

    Main Methods:

    • Clinical evaluation of a 3-year-old child with SLE and evidence of defective cellular immunity.
    • Postmortem examination of renal, neural, and thymic tissues.
    • Morphological analysis of intracytoplasmic structures and cellular components.

    Main Results:

    • Paramyxovirus-like tubular structures were identified in the kidneys of the SLE patient.
    • Intracytoplasmic viral particles resembling herpes simplex virus were found in neurons.
    • The patient's thymus gland showed lymphocyte depletion and absence of Hassall corpuscles, indicative of thymic dysplasia.

    Conclusions:

    • The findings suggest a potential association between viral-like particles, thymic dysplasia, and immune deficiency in SLE.
    • Further research is warranted to explore the role of viruses in the pathogenesis of SLE.
    • The observed 'nuclear bodies' may also be significant in the context of SLE pathology.

    More Related Videos

    Skin Biopsy for Diagnosing Discoid Lupus Erythematosus05:44

    Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

    Published on: June 10, 2025

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus05:39

    Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

    Published on: May 16, 2025

    Related Concept Videos

    Autoimmune Disorders01:29

    Autoimmune Disorders

    Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
    Concept and Mechanism of Autoimmune Diseases
    The immune system...
    Nephrotic Syndrome I : Introduction01:24

    Nephrotic Syndrome I : Introduction

    Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
    Multiple Sclerosis l: Introduction01:19

    Multiple Sclerosis l: Introduction

    Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
    Hypersensitivity Reactions: Immune-Complex Reactions01:19

    Hypersensitivity Reactions: Immune-Complex Reactions

    Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...