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Updated: Aug 13, 2026
Construction and Application of Cerebral Functional Region-Based Cerebral Blood Flow Atlas Using Magnetic Resonance Imaging-Arterial Spin Labeling
Published on: May 31, 2024
Perfusion imaging of meningioma by using continuous arterial spin-labeling: comparison with dynamic
H Kimura1, H Takeuchi, Y Koshimoto
1Department of Radiology, Faculty of Medical Science, University of Fukui, Fukui, Japan.
Purpose:
The goal of the present study was to determine the utility of continuous arterial spin labeling (CASL) for characterization of meningioma by MR perfusion imaging and to compare these results with those obtained from the T2 dynamic susceptibility contrast (T2DSC) method and from histopathologic examination.
Methods:
Twenty-one cases of meningiomas were examined at 1.5T. CASL perfusion imaging was implemented on the basis of multisection single-shot echo-planar imaging with velocity-driven adiabatic spin-inversion preparation. T2DSC perfusion imaging was also performed by using a double-echo spoiled gradient echo sequence in a section containing the tumor. By focusing on the regions of interest, maps of % signal intensity change and cerebral blood flow (CBF) were determined from CASL and cerebral blood volume (CBV). CBF and mean transit time (MTT) were obtained from T2DSC. The microvessel area (MVA) was determined from specimens immunostained with anti-CD31 in 14 cases by measuring the total amount of staining in each histologic section. Linear regression analysis was performed for rCBF values from both perfusion methods and for % signal intensity change and MVA.
Results:
There was a significant correlation between CBF values determined from both perfusion methods (r(2) = 0.73; P < .001); however, the slope from T2DSC to CASL was less than unity, likely because of the different vascular weighting used for each method. There was also a significant correlation between CASL-% signal intensity change and MVA determined by histopathology (r(2) = 0.91; P < .00001). Perfusion values were the greatest for angiomatous meningioma and lowest for fibrous meningioma when using either perfusion method.
Conclusions:
CASL and T2DSC perfusion methods are comparable in the characterization of meningiomas. Further, CASL is of use in assessing tumor microcirculation.
Insights
Continuous arterial spin labeling (CASL) and T2 dynamic susceptibility contrast (T2DSC) are comparable for characterizing meningiomas. CASL is also useful for assessing tumor microcirculation and correlates well with histopathology.
Area of Science:
- Neuroradiology
- Medical Imaging
- Oncology
Background:
- Meningiomas are common primary tumors of the central nervous system.
- Accurate characterization of meningiomas is crucial for treatment planning.
- MR perfusion imaging offers non-invasive methods for assessing tumor vascularity.
Purpose of the Study:
- To evaluate the utility of continuous arterial spin labeling (CASL) for meningioma characterization.
- To compare CASL perfusion imaging with T2 dynamic susceptibility contrast (T2DSC) and histopathology.
- To assess the correlation between CASL-derived metrics and microvessel area (MVA).
Main Methods:
- Twenty-one meningioma cases were studied using 1.5T MR.
- CASL and T2DSC perfusion imaging techniques were applied.
- Histopathologic analysis included anti-CD31 immunostaining for MVA determination.
Main Results:
- Significant correlation found between cerebral blood flow (CBF) from CASL and T2DSC (r² = 0.73).
- Strong correlation observed between CASL-% signal intensity change and MVA (r² = 0.91).
- Perfusion values varied significantly between meningioma subtypes (angiomatous vs. fibrous).
Conclusions:
- CASL and T2DSC are comparable for meningioma characterization.
- CASL is valuable for assessing tumor microcirculation.
- CASL shows strong agreement with histopathologic findings of microvessel area.
