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Angiosarcoma metastatic to the orbit.

Michael Brush1, Jing Zhang, Scott Schuetze

  • 1Department of Ophthalmology, University of Washington, Seattle, 98195, USA.

Ophthalmic Plastic and Reconstructive Surgery
|January 19, 2006
PubMed
Summary

Metastatic orbital angiosarcoma in a 61-year-old woman showed partial response to chemotherapy (paclitaxel, doxorubicin, ifosfamide) and radiotherapy. While not curative, chemotherapy offered palliative benefit and extended survival compared to a similar case.

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Area of Science:

  • Oncology
  • Ophthalmology
  • Pathology

Background:

  • Metastatic angiosarcoma of the orbit is a rare and aggressive malignancy.
  • Optimal treatment strategies for orbital angiosarcoma remain challenging.

Observation:

  • A 61-year-old woman presented with metastatic angiosarcoma in the left orbit.
  • Diagnosis was histologically confirmed with special markers via incisional orbital biopsy.

Findings:

  • The patient received multi-agent chemotherapy (paclitaxel, doxorubicin, ifosfamide) and adjuvant radiotherapy.
  • Chemotherapy resulted in tumor mass reduction, indicating a palliative response.
  • Disease progression occurred after cessation of chemotherapy, ultimately leading to mortality.

Implications:

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  • Chemotherapy may serve as a palliative adjunct in managing metastatic orbital angiosarcoma.
  • While unlikely to be curative, chemotherapy can be a useful addition to surgery and radiation therapy.
  • This case contributes to understanding treatment outcomes in rare orbital malignancies.