Related Experiment Video
Updated: Aug 13, 2026

CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
Published on: August 4, 2016
Syntaxin 9 is enriched in skin hair follicle epithelium and interacts with the epidermal growth factor receptor
Ya Wang1, Ling Yann Foo, Ke Guo
1Department of Biochemistry, Yong Lou Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore 117597.
Abstract:
We describe a novel syntaxin family member, syntaxin 9 (Syn 9), which does not possess a typical C-terminal hydrophobic tail anchor. Syn 9 has, however, a Q-SNARE domain and an overall homology to syntaxins (with the highest overall homology with mammalian syntaxin 11). Syn 9 is enriched in some epithelial cells, particularly that of the stomach lining and the skin. At the skin, it is found in the epidermal layers as well as structures associated with hair follicles. A biochemical interaction screen revealed that Syn 9 interacts specifically with the epidermal growth factor (EGF) receptor. Overexpression of Syn 9 perturbed EGF receptor endocytosis but does not appear to affect the internalization of the transferrin receptor. Syn 9 may therefore have a role in EGF receptor transport and signaling in certain epithelial cell types.
Related Concept Videos
Septins
Tail-anchoring of Proteins in the ER Membrane
Multipotency and Niche of Bulge Stem Cell
Renewal of Skin Epidermal Stem Cells
Overview of Secretory Vesicles
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Structural Protein Function
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
