Related Experiment Video
Updated: Aug 13, 2026
Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
[Pharmacokinetic study of intraperitoneal chemotherapy with HCPT]
Meng Ye1, Xiao-xia Lin, Hong-ming Pan
1Oncology center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310016, China.
Objective:
To study the pharmacokinetic of 10-Hydroxycamptothecin HCPT by intraperitoneal administration.
Method:
Six dogs were given HCPT by intraperitoneal perfusion: HCPT 2 mg x kg(-1), dissolved in 300 mL NS. During the course of experiments, peritoneal fluids and blood were sampled using a standardized protocol. The concentration of HCPT in all samples was determined by high performance liquid chromatography (HPLC).
Result:
The area under the curve (AUC) of peritoneal fluids was significantly highly as compared to the AUC of femoral vein and portal vein (P < 0.001).
Conclusion:
These experiments demonstrate that intraperitoneal chemotherapy has significant effect on the pharmacokinetics of IP route of HCPT administration. This method should be a more reasonable chemotherapy for the prevention of recurrence and liver metastasis of gastric cancer, colon cancer and ovary cancer after radical resection.
