Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Uveitis associated with human T-cell lymphotropic virus type I.

M Mochizuki1, T Watanabe, K Yamaguchi

  • 1Department of Ophthalmology, Kurume University School of Medicine, Japan.

American Journal of Ophthalmology
|August 15, 1992
PubMed
Summary

Human T-cell lymphotropic virus type I (HTLV-1) is significantly associated with uveitis, particularly intermediate uveitis. Higher HTLV-1 seroprevalence in uveitis patients suggests a causal link, distinct from other common ocular inflammatory diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax.

Blood·1995
Same author

Expression of AML1 and ETO Transcripts in hematopoietic cells.

Leukemia·1995
Same author

HTLV-II detection in an Amerindian family in Colombian southern Andean region.

Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association·1995
Same author

Expression of Fas/Apo-1 (CD95) and apoptosis in tumor cells from patients with plasma cell disorders.

Blood·1995
Same author

Soluble c-kit molecule in serum from healthy individuals and patients with haemopoietic disorders.

British journal of haematology·1995
Same author

Proposal for a classification of the clinical stages of paroxysmal nocturnal hemoglobinuria.

Blood·1995

Area of Science:

  • Ophthalmology
  • Virology
  • Immunology

Background:

  • Investigating the association between Human T-cell lymphotropic virus type I (HTLV-1) and uveitis.
  • Comparing HTLV-1 seroprevalence in endemic and less endemic regions.

Observation:

  • Significantly higher HTLV-1 seroprevalence in uveitis patients without defined causes (35.4%) compared to controls.
  • Elevated seroprevalence observed in younger uveitis patients (20-49 years) in endemic areas.
  • Similar trends noted in a less endemic region, supporting the association.

Findings:

  • HTLV-1 seroprevalence in uveitis patients (35.4%) was substantially higher than in non-uveitic ocular diseases (16.1%) and uveitis with defined causes (10.3%).
  • Younger patients (20-49 years) with idiopathic uveitis showed a markedly higher HTLV-1 seroprevalence (44.8%) compared to controls (9.3%).

Related Experiment Videos

  • The observed pattern contradicts typical age-related seroprevalence, strengthening the link between HTLV-1 and uveitis.

    • Implications:

    • HTLV-1 is a significant causative agent for intermediate uveitis, iritis, and retinal vasculitis.
    • Findings suggest HTLV-1-associated uveitis presents distinct clinical features compared to other common forms in Japan.
    • This research highlights the importance of HTLV-1 screening in patients with unexplained intermediate uveitis.