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Pediatric reference intervals for bone markers.

Liju Yang1, Vijaylaxmi Grey

  • 1Department of Pathology and Molecular Medicine, Hamilton Regional Laboratory Medicine Program, McMaster University Medical Centre, McMaster University, Room 2N17, 1200 Main Street W, Hamilton, ON, Canada L8N 3Z5.

Clinical Biochemistry
|January 21, 2006
PubMed
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Bone markers, reflecting bone remodeling, are elevated in children due to growth. This review covers advances in measuring bone formation and resorption markers for pediatric skeletal health.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Endocrinology

Background:

  • Bone markers are molecules indicating bone remodeling activity.
  • Children exhibit higher bone marker levels due to rapid growth and bone turnover.
  • Factors influencing bone metabolism in children are diverse, encompassing physiological and pathological processes.

Purpose of the Study:

  • To review recent advancements in analytical methods for bone markers in children.
  • To highlight key bone formation markers (bone alkaline phosphatase, osteocalcin) and resorption markers (pyridinium cross-links, cross-linked telopeptides).
  • To discuss age- and sex-specific pediatric reference intervals and their clinical application limitations.

Main Methods:

  • Review of recent literature on bone marker analysis in pediatric populations.

Related Experiment Videos

  • Focus on analytical techniques and preanalytical considerations for specific bone markers.
  • Synthesis of information on established and emerging bone markers relevant to childhood skeletal health.

    • Main Results:

    • Significant advances in analytical methods for bone markers have been documented.
    • Bone alkaline phosphatase and osteocalcin are key bone formation markers.
    • Pyridinium cross-links and cross-linked telopeptides are important bone resorption markers.
    • Pediatric reference intervals require careful consideration of age and sex, with noted limitations.

    Conclusions:

    • Bone marker measurements are valuable for diagnosing skeletal diseases in children and monitoring treatment efficacy.
    • Understanding analytical and preanalytical factors is crucial for accurate bone marker assessment in pediatric patients.
    • Further research into pediatric reference intervals is needed to optimize clinical application of bone markers.