Related Experiment Video
Updated: Aug 13, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Headache in Behçet's disease
E Aykutlu1, B Baykan, G Akman-Demir
1Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Cephalalgia : an International Journal of Headache
|January 24, 2006
Summary
Headaches in Behçet's disease (BD) are often primary, like migraine or tension-type headache (TTH), not always indicating neurological issues. Some migraines in BD patients are linked to systemic inflammation and respond to its treatment.
Area of Science:
- Neurology
- Rheumatology
- Headache Medicine
Background:
- Behçet's disease (BD) is a multisystem inflammatory disorder.
- Headache is a common symptom in BD patients, but its characteristics and relationship to neurological involvement require detailed investigation.
Purpose of the Study:
- To investigate the specific characteristics of headaches experienced by patients with Behçet's disease.
- To differentiate between primary and secondary headaches in BD patients and explore potential triggers and associations with disease activity.
Main Methods:
- A retrospective electronic database study of consecutive Behçet's disease patients attending a neuro-Behçet's outpatient clinic.
- Headaches were classified according to the International Headache Society criteria.
- Analysis of headache types, prevalence, and association with BD systemic flare-ups and neurological involvement.
Main Results:
- Out of 118 BD patients, 98 reported headaches.
- Migraine was the most frequent primary headache (46.4%), followed by tension-type headache (TTH) (26.8%).
- Secondary headaches, often due to cerebral venous thrombosis or neuro-BD, occurred in 37 patients; 15 had both primary and secondary headaches. Primary headaches were exacerbated by BD flare-ups in 13 patients, and four experienced migraines triggered solely by BD activation, responding well to anti-inflammatory treatment.
Conclusions:
- The majority of headaches in Behçet's disease patients are primary types (migraine, TTH) and do not necessarily signify neurological involvement.
- A subset of BD patients experiences migraines associated with systemic inflammation, which can be effectively managed by treating the underlying inflammation.
Related Concept Videos
01:14Increased Intracranial Pressure l: Introduction
Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
01:17Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
01:29Increased Intracranial Pressure ll: Pathophysiology
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...