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Getting a grip on licensing: mechanism of stable Mcm2-7 loading onto replication origins
Christin A Cvetic1, Johannes C Walter
1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02446, USA.
Molecular Cell
|January 24, 2006
Abstract:
A recent Molecular Cell paper by Randell et al. (2006) sheds light on the role of ATP hydrolysis by Cdc6 in promoting the stable loading of the Mcm2-7 complex onto origins of DNA replication.
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