Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

3.5K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.5K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

9.2K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
9.2K
Discharge Summary Forms01:31

Discharge Summary Forms

1.3K
The discharge summary is crucial as it enables a smooth transition from a healthcare facility to a patient's home or another care setting. This critical document facilitates seamless continuity of care, ensuring patients receive the necessary support and attention.
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
1.3K
Production of Formed Elements01:34

Production of Formed Elements

4.7K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
4.7K
Cartesian Form for Vector Formulation01:26

Cartesian Form for Vector Formulation

1.1K
The Cartesian form for vector formulation is a process to calculateĀ  the moment of force using the position and force vectors. The moment of force is defined as the cross-product of these vectors, making it a vector quantity. The Cartesian form of the position and force vectors involves unit vectors, which can be used to express the cross-product in determinant form.
1.1K
Functional Groups02:45

Functional Groups

88.5K
Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
88.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets.

Blood advancesĀ·2018
Same author

Sarcomeric and nonmuscle Ī±-actinin isoforms exhibit differential dynamics at skeletal muscle Z-lines.

Cytoskeleton (Hoboken, N.J.)Ā·2018
Same author

Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

BloodĀ·2016
Same author

An adventitious interaction of filamin A with RhoGDI2(Tyr153Glu).

Biochemical and biophysical research communicationsĀ·2015
Same author

Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.

Nature communicationsĀ·2015
Same author

FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

BloodĀ·2015
Same journal

Pain in SCD-Many mechanisms and mysteries.

Seminars in hematologyĀ·2026
Same journal

The many facets of cardiopulmonary complications in sickle cell disease.

Seminars in hematologyĀ·2026
Same journal

Clonal hematopoiesis in the setting of sickle cell disease and its relevance to curative therapies.

Seminars in hematologyĀ·2026
Same journal

Treatment of myeloproliferative neoplasms: Exploring new horizons of who and when to cytoreduce in patients with polycythemia vera and essential thrombocytosis.

Seminars in hematologyĀ·2026
Same journal

Telomeres biology disorders: the past, the present and the future.

Seminars in hematologyĀ·2026
Same journal

Cardiovascular complications in patients with myeloproliferative neoplasms: What hematologists need to know.

Seminars in hematologyĀ·2026
See all related articles

Related Experiment Video

Updated: Feb 1, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

805

The platelet: form and function.

John H Hartwig1

  • 1Division of Hematology, Karp Family Research Laboratories, Brigham and Women's Hospital, Boston, MA 02115, USA. hartwig@rics.bwh.harvard.edu

Seminars in Hematology
|January 24, 2006
PubMed
Summary
This summary is machine-generated.

Platelets are small cell fragments crucial for vascular integrity. Their cytoskeleton dictates their shape, enabling rapid transformation from resting discs to active forms that repair injuries.

More Related Videos

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K

Related Experiment Videos

Last Updated: Feb 1, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

805
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

1.2K
Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K

Area of Science:

  • Hematology
  • Cell Biology
  • Biophysics

Background:

  • Platelets are essential for hemostasis and vascular repair.
  • Their discoid resting shape is maintained by an internal cytoskeleton.
  • Upon vascular injury, platelets undergo rapid morphological and functional changes.

Purpose of the Study:

  • To review the critical role of the platelet cytoskeleton.
  • To explain how cytoskeletal dynamics define resting and active platelet states.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on the structural and functional aspects of platelet cytoskeleton.

Main Results:

  • The microtubule and actin cytoskeleton define the platelet's resting discoid shape.
  • Cytoskeletal disassembly and rapid actin filament assembly drive the transformation to the active, spread form.
  • Actin assembly generates forces for platelet spreading and filopodia formation.

Conclusions:

  • The platelet cytoskeleton is central to its function in vascular repair.
  • Dynamic cytoskeletal remodeling underlies the transition between resting and active platelet states.