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Updated: Aug 13, 2026

Assessment of Long-term Depression Induction in Adult Cerebellar Slices
Published on: October 16, 2019
Experience-dependent modification of mechanisms of long-term depression
Jihoon Jo1, Simon M Ball, Heon Seok
1Biomedical Science, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.
Abstract:
Mechanisms of long-term potentiation and depression (LTP and LTD) change considerably during development, but the importance of these changes and the factors that control them is not clear. We found that visual experience triggered a switch in mechanisms of LTD in rat perirhinal cortex, an area critical for visual recognition memory. Thus, changes in synaptic plasticity mechanisms were correlated with the changing physiological demands on the CNS.
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