Developing an integrated brain resource framework for translational neuroscience in Korea Brain Bank

Area of Science:

• Neuroscience
• Biobanking
• Data Science

Background:

• The Korea Brain Research Institute (KBRI) established the Korea Brain Bank (KBB) to create a national framework for human brain banking.
• The KBB operates the Korean Brain Bank Network (KBBN), a nationwide system comprising eight network hospitals, supported by the Ministry of Science and ICT (MSIT).

Purpose of the Study:

• To establish a national framework integrating human brain banking with digital and multi-omics resources to strengthen translational neuroscience in Korea.
• To enhance data interoperability, standardization, and accessibility across the national network.
• To address limitations in securing brain resources for psychiatric disorders through international collaboration.

Main Methods:

• Implementing the Brain Resource Archive Management System (BRAMS) for integrated management of human brain resources.
• Prioritizing collection of brain resources from neurodegenerative disorder patients for neuropathological assessment and digital dataset construction.
• Expanding international collaborations to develop specialized psychiatric cohorts for multi-omics studies.

Main Results:

• Measurable improvements in data completeness, resource utilization efficiency, and research connectivity within the KBBN.
• Successful establishment of a centrally coordinated nationwide brain bank network.
• Identification of sociocultural barriers limiting brain donation for psychiatric disorders.

Conclusions:

• The KBBN framework enhances brain resource management and research connectivity in Korea.
• Future strategies include integrating advanced omics technologies, iPSC/organoid models, and AI-assisted data governance for a comprehensive Brain Atlas Hub.
• The KBB aims to advance responsible and sustainable brain resource management through innovation and global cooperation.