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Published on: November 8, 2015
Intravenous pulse cyclophosphamide therapy in focal segmental glomerulosclerosis
M Buyukcelik1, N Cengiz, H Dursun
1Department of Pediatric Nephrology, Cukurova University, School of Medicine Adana, Adana, Turkey. buyukcelikm66@yahoo.com
Clinical Nephrology
|January 25, 2006
Summary
Intravenous pulse cyclophosphamide (IVCP) showed limited benefit for steroid-resistant focal segmental glomerulosclerosis (FSGS). This therapy may be considered for patients unresponsive to other treatments, including those with primary steroid resistance.
Area of Science:
- Nephrology
- Immunosuppressive Therapy
Background:
- Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease.
- Steroid-resistant FSGS presents a significant treatment challenge.
- Previous therapies, including steroids and other immunosuppressants, were ineffective in these patients.
Purpose of the Study:
- To evaluate the efficacy of intravenous pulse cyclophosphamide (IVCP) in patients with steroid-resistant FSGS.
- To assess IVCP as a potential treatment for primary steroid-resistant FSGS.
Main Methods:
- Five patients with steroid-resistant FSGS received monthly IVCP (500 mg/m2) for 6 months.
- Concurrent oral prednisone therapy was administered and tapered.
- Treatment was continued if a response was observed; otherwise, it was discontinued.
Main Results:
- Only one out of five patients achieved remission with IVCP.
- Four patients showed no response to IVCP.
- Two non-responders progressed to end-stage renal disease (ESRD); two others initiated cyclosporine therapy. No adverse effects were reported.
Conclusions:
- IVCP demonstrated limited efficacy in treating steroid-resistant FSGS.
- IVCP may be a therapeutic option for steroid-resistant FSGS, particularly in primary resistant cases or those refractory to other immunosuppressants.
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