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Role of transcription factors in commitment and differentiation of early B lymphoid cells

Stephanie Roessler1, Rudolf Grosschedl

  • 1Max-Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, Stubeweg 51, 79108 Freiburg, Germany.

Seminars in Immunology
|January 25, 2006
PubMed

B lymphopoiesis is a differentiation process in which hematopoietic stem cells are converted into antibody-producing plasma cells. B cell differentiation involves multiple steps, including cell specification, commitment to the B cell lineage, immunoglobulin rearrangements, maturation of B cells and terminal differentiation into plasma cells. Each of these steps is controlled by signaling pathways and transcription factors that act in synergy, feedback-loops or cross-antagonism to generate complex regulatory networks that allow for plasticity and stability of B cell differentiation.

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