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Related Experiment Videos

Evolution of circular permutations in multidomain proteins.

January Weiner1, Erich Bornberg-Bauer

  • 1Division of Bioinformatics, School of Biological Sciences, University of Münster, Schlossplatz 4, Münster, Germany. january@uni-muenster.de

Molecular Biology and Evolution
|January 25, 2006
PubMed
Summary

Protein modular rearrangements, including circular permutations, are key to evolution. Analysis reveals gene duplication, fusion, and loss drive these changes, with independent fusion/fission being most common.

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Area of Science:

  • Evolutionary Biology
  • Molecular Biology
  • Bioinformatics

Background:

  • Modular rearrangements, involving conserved protein domains, are crucial for protein evolution.
  • These rearrangements can alter the sequential order of domains, leading to circularly permuted proteins.
  • Understanding the genetic mechanisms behind these rearrangements is vital for evolutionary studies.

Purpose of the Study:

  • To identify and analyze the evolutionary history of modular rearrangements, specifically circular permutations.
  • To investigate the genetic mechanisms responsible for these protein rearrangements.

Main Methods:

  • Utilized a recently developed algorithm to identify a large number of protein rearrangements.
  • Analyzed the evolutionary history of identified rearrangements.

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  • Categorized rearrangements based on three postulated genetic mechanisms: independent fusion/fission, duplication/deletion, and plasmid-mediated cut and paste.

    • Main Results:

    • Identified numerous instances of modular rearrangements and circular permutations.
    • Confirmed that independent fusion/fission, duplication/deletion, and cut and paste mechanisms contribute to these rearrangements.
    • Found independent fusion/fission to be the most frequent mechanism, partly due to highly mobile domains.

    Conclusions:

    • All three investigated genetic mechanisms (independent fusion/fission, duplication/deletion, cut and paste) are active in driving protein modular rearrangements.
    • Independent fusion/fission is the predominant mechanism, highlighting the role of mobile domains in protein evolution.
    • The findings provide insights into the evolutionary pathways of modular proteins, such as peptide synthases.