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Numerical study of arterial flow during sustained external acceleration.

D A Cornet1, D F Young, T R Rogge

  • 1Biomedical Engineering Program, Iowa State University, Ames 50011.

Biomedical Sciences Instrumentation
|January 1, 1992
PubMed
Summary

This study models the human arterial tree to analyze how sustained acceleration (+Gz) affects eye-level blood pressure and flow. The computer model accurately simulates physiological responses, including those from anti-G suits and arterial stenosis.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Physiology
  • Computational Fluid Dynamics

Background:

  • Sustained acceleration (+Gz) poses risks to cardiovascular health, particularly affecting blood flow and pressure.
  • Understanding the human arterial tree's response to G-forces is crucial for aerospace and defense applications.
  • Existing models often simplify complex physiological compensatory mechanisms.

Purpose of the Study:

  • To develop and validate a one-dimensional computer model of the human arterial tree.
  • To investigate the effects of sustained acceleration (+Gz) on eye-level arterial pressure and flow.
  • To simulate the impact of anti-G suits and carotid stenosis on cardiovascular responses during acceleration.

Main Methods:

  • Utilized one-dimensional flow equations to model the human arterial tree.

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  • Incorporated steady-state physiological compensatory mechanisms based on human centrifuge data.
  • Simulated various scenarios: supine and standing positions (+1 Gz), resistive and occlusive anti-G suits, and proximal carotid stenosis.

    • Main Results:

    • The computer model successfully simulated eye-level arterial pressure and flow under different conditions.
    • Model predictions showed satisfactory correspondence with existing literature data.
    • The study demonstrated the model's capability to replicate physiological responses to acceleration and interventions.

    Conclusions:

    • The developed computer model provides a valuable tool for studying cardiovascular responses to sustained acceleration.
    • The findings highlight the importance of physiological compensation and the potential impact of interventions like anti-G suits.
    • Further research can utilize this model to explore other physiological challenges and protective strategies.