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Updated: Aug 13, 2026

Direct and Indirect Culture Methods for Studying Biodegradable Implant Materials In Vitro
Published on: April 15, 2022
Delayed degradation in a resorbable plating system
Richard Mackool1, Jun Yim, Joseph G McCarthy
1Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY, USA.
Abstract:
Resorbable plating systems are used extensively for craniofacial reconstruction, particularly in children. The systems provide rigid fixation while potentially minimizing the long-term drawbacks of permanent plating systems such as plate "migration," bone growth restriction, and imaging artifact. However, the need for active plate resorption represents both the strength and weakness of these fixation systems. We present four patients who underwent cranial vault remodeling using a resorbable plating system, following which the plates were palpable and observable for at least 2 years postoperatively. All required surgical removal. On gross inspection, the plates had been replaced by an encapsulated spongy material containing yellow, grainy, cloudy liquid. The bone underlying the plates was depressed and irregular in contour when compared with the adjacent bone. Microscopic studies showed a giant cell foreign-body reaction with crystalline material present in the cell vacuoles.
