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Multiple common naevi in Israeli adolescents
Tal Friedman1, Yonit Wohl, Avi Levin
1Medical Corps, Israel Defence Forces, Tel Aviv, Israel.
Melanoma Research
|January 25, 2006
Summary
Melanoma risk is linked to numerous moles. This study found higher prevalence of multiple moles in 17-year-old Israelis of American/European origin and those living in coastal cities.
Area of Science:
- Dermatology
- Epidemiology
- Genetics
Background:
- Multiple common melanocytic naevi are a significant phenotypic risk factor for melanoma.
- Understanding the prevalence and associated risk factors of multiple naevi is crucial for melanoma prevention strategies.
Purpose of the Study:
- To determine the prevalence of multiple common naevi (defined as >50 naevi) in 17-year-old Jewish Israelis.
- To identify potential risk factors associated with this phenotype, including origin, education, and residence.
Main Methods:
- A cross-sectional study of approximately 100,000 17-year-old Israeli conscripts (40,000 female, 60,000 male) from 2003-2004.
- Whole-body naevi counts were performed by military physicians.
- Data collected included naevi count, education level, place of birth, and residence of recruits and their ancestors.
Main Results:
- The prevalence of the multiple naevi phenotype was highest among recruits of American origin and lowest among those of Asian and African origin (P < 0.0001).
- Prevalence was highest in coastal cities (Haifa, Tel Aviv), correlating with melanoma distribution.
- Among males, the phenotype was more common in those with higher education (> or =12 years) (P = 0.051).
Conclusions:
- A high count of common naevi in young adults is associated with American/European origin and coastal residence.
- These findings highlight the interplay of endogenous and exogenous factors in melanoma development.
- The study provides valuable epidemiological data on naevus prevalence and melanoma risk factors in a specific population.
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