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The Masquelet Technique: Is Bone Regeneration Influenced by Biological Sex?
Jasper Frese1, Julius J Hahne2, Cornelius Grimme1
1Department of Septic Bone and Joint Surgery, BG Klinikum Hamburg, Bergedorfer Straße, Hamburg, Germany.
Strategies in Trauma and Limb Reconstruction
|August 12, 2026
Summary
This study found no significant differences in treatment outcomes for the Masquelet technique between male and female patients. Both sexes achieved similar full weight-bearing capacity and experienced comparable complication rates, indicating sex does not influence therapeutic results.
Area of Science:
- Orthopedic surgery
- Reconstructive surgery
- Trauma surgery
Background:
- Existing research on the Masquelet technique lacks gender-specific outcome analysis.
- This study addresses the gap by investigating sex-based differences in therapeutic results.
Purpose of the Study:
- To determine if biological sex influences the outcomes of the Masquelet technique.
- To compare treatment results between male and female patients undergoing the Masquelet procedure.
Main Methods:
- Retrospective cohort study of 171 patients (58 women, 113 men) treated with the Masquelet technique.
- Systematic assessment of defect characteristics, complications, surgical revisions, and weight-bearing achievement.
- No sex-specific treatment protocols were applied.
Main Results:
- No significant difference in achieving full weight-bearing capacity between sexes (87.9% women vs. 90.3% men).
- Similar average time to full weight-bearing (21 months) for both male and female patients.
- Comparable complication rates observed (50% women vs. 57% men).
Conclusions:
- Biological sex does not appear to significantly impact therapeutic outcomes of the Masquelet technique.
- Factors like age, comorbidities, defect size, and location were comparable between sexes.
- The Masquelet technique demonstrates consistent efficacy regardless of patient sex.
