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One pot synthesis of selenocysteine containing peptoid libraries by Ugi multicomponent reactions in water

Muhammad Abbas1, John Bethke, Ludger A Wessjohann

  • 1Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.

Chemical Communications (Cambridge, England)
|January 25, 2006
PubMed

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.