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Prokinetic agents in childen with poor appetite.

O Bekem1, B Buyukgebiz, A Aydin

  • 1Dokuz Eylul University Faculty of Medicine, Department of Pediatrics, Izmir, Turkey. obekem@yahoo.com

Acta Gastro-Enterologica Belgica
|January 26, 2006
PubMed
Summary

Prokinetic agents combined with behavioral feeding strategies significantly improved appetite in children with poor eating habits and delayed gastric emptying. This approach also led to improvements in weight and height, reducing malnutrition rates.

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Area of Science:

  • Pediatric Gastroenterology
  • Clinical Nutrition
  • Pharmacology

Background:

  • Poor appetite is a common pediatric feeding disorder, often linked to underlying gastric motility issues.
  • Delayed gastric emptying can significantly impact a child's nutritional status and overall well-being.

Purpose of the Study:

  • To investigate the efficacy of prokinetic agents in treating poor appetite in children.
  • To assess the impact of prokinetics on delayed gastric emptying and nutritional parameters.

Main Methods:

  • Utilized visual analogue scale (VAS) for appetite grading and 99mTechnetium tincolloid scintigraphy for gastric emptying assessment.
  • Administered trimebutine (a prokinetic agent) for 6 months alongside behavioral feeding recommendations.
  • Monitored anthropometrical measurements, energy intake, and repeated scintigraphy during the study period.

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Main Results:

  • Significant improvements observed in weight and height standard deviation scores (p=0.008 and p=0.003, respectively).
  • Malnutrition rates decreased from 81% to 66.7% following the intervention.
  • Appetite scores (VAS) showed significant improvement (p=0.012), though gastric emptying changes were not statistically significant (P=0.059).

Conclusions:

  • Prokinetic therapy, when combined with behavioral feeding recommendations, shows promise for children experiencing poor appetite and delayed gastric emptying.
  • The study suggests a potential benefit of this combined approach in improving nutritional outcomes and appetite in pediatric patients.