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Related Experiment Videos

Potential candidates for small bowel transplantation.

C L Ingham Clark1, P A Lear, S Wood

  • 1Professorial Surgical Unit, St Bartholomew's Hospital, London, UK.

The British Journal of Surgery
|July 1, 1992
PubMed
Summary

Estimating the need for small bowel transplantation in the UK, this study found that 10 of 25 adult patients on parenteral nutrition were potential candidates. This suggests up to 20 new adult patients annually may benefit from this life-saving procedure.

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Area of Science:

  • Gastroenterology
  • Transplantation Surgery
  • Clinical Research

Background:

  • Irreversible small intestinal failure necessitates permanent parenteral nutrition.
  • The prevalence of eligible candidates for small bowel transplantation in the UK is not well-defined.
  • Small bowel transplantation offers a potential solution for end-stage intestinal failure.

Purpose of the Study:

  • To estimate the number of potential adult candidates for small bowel transplantation in the UK.
  • To identify factors influencing suitability for small bowel transplantation.
  • To inform national healthcare planning for intestinal failure management.

Main Methods:

  • Retrospective analysis of adult patients receiving permanent parenteral nutrition.
  • Assessment of patient suitability based on defined clinical criteria.

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  • Extrapolation of findings to estimate national incidence.

    • Main Results:

    • Out of 25 adult patients receiving parenteral nutrition, 10 (40%) were identified as potential small bowel transplant recipients.
    • The primary reasons for unsuitability included multiple prior abdominal surgeries and intra-abdominal abscesses.
    • The study suggests an annual incidence of up to 20 new adult candidates for small bowel transplantation in the UK.

    Conclusions:

    • A significant number of adult patients with irreversible small intestinal failure may be candidates for small bowel transplantation.
    • Patient selection requires careful consideration of surgical history and absence of complications.
    • These findings highlight the potential need for expanded small bowel transplantation services in the UK.