Related Experiment Video
Updated: Aug 13, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Androgen excess disorders in women: the severe insulin-resistant hyperandrogenic syndrome, HAIR-AN
Kristin M Rager1, Hatim A Omar
1Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Abstract:
HAIR-AN syndrome (hyperandrogenism, insulin resistance, acanthosis nigricans) is a subset of the polycystic ovary syndrome, where the patients demonstrate severe insulin resistance. It is theorized that both genetic and environmental factors, such as obesity, give rise to the development of HAIR-AN. Diagnosis is primarily clinical, with laboratory values lending further support. Treatment is aimed at decreasing insulin resistance, regulating ovulation, and decreasing acne, acanthosis nigricans, and hirsutism.
Related Concept Videos
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Type I Diabetes III: Clinical Manifestations
Disorders of the Female Reproductive System
Hyperthyroidism I: Introduction
Hyperthyroidism II: Pathophysiology
Cirrhosis I: Introduction

