Related Experiment Video
Updated: Aug 1, 2026
11:13
Identification of Kinase-substrate Pairs Using High Throughput Screening
Published on: August 29, 2015
Protein kinase resource: an integrated environment for phosphorylation research
Roland H Niedner1, Oleksandr V Buzko, Nina M Haste
1San Diego Supercomputer Center, University of California San Diego, La Jolla, California 92093, USA.
Proteins
|January 26, 2006
Summary
The Protein Kinase Resource offers an integrated online service for cell signaling research. It provides access to visualized and analyzed data on protein kinases, aiding in understanding cellular processes.
Area of Science:
- Biochemistry
- Cell Biology
- Bioinformatics
Background:
- Protein kinases are crucial enzymes regulating cellular signaling pathways.
- Abundant experimental data necessitates integrated platforms for analysis.
- Understanding kinase signaling is key to deciphering cellular processes.
Purpose of the Study:
- To introduce the Protein Kinase Resource (PKR), an integrated online service.
- To provide researchers with tools for visualizing and analyzing protein kinase data.
- To facilitate a deeper understanding of cell signaling and kinase functions.
Main Methods:
- Integrated online service synchronized with UniProt and PDB databases.
- Data annotation includes domain composition, ortholog cross-references, and OMIM mapping.
- Interactive visualization of human kinome tree and sequence/structure data.
- Advanced search functionalities (multiparameter, pattern, BLAST) and statistical analysis tools.
Main Results:
- The PKR provides a unified view of the protein kinase superfamily.
- Data is regularly updated and verified, ensuring accuracy.
- Interactive tools enable direct data visualization and analysis within the online environment.
- Efficient data access and relationship analysis among kinases are facilitated.
Conclusions:
- The Protein Kinase Resource enhances cell signaling research through integrated data and visualization.
- The platform's design can serve as a model for other scientific data providers.
- PKR offers an effective approach to accessing and analyzing experimental kinase information.
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