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Tissue penetration of telavancin after intravenous administration in healthy subjects
Heather K Sun1, Kenneth Duchin, Charles H Nightingale
1Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA.
Antimicrobial Agents and Chemotherapy
|January 27, 2006
Abstract:
The pharmacokinetic disposition of telavancin administered 7.5 mg/kg of body weight every 24 h was determined in plasma and skin blister fluid. The mean penetration of telavancin into blister fluid was 40%. This study reveals that adequate concentrations are achieved in both plasma and blister fluid for pathogens frequently implicated in skin and soft tissue infections.

