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Updated: Aug 13, 2026
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A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
Decreased mortality by normalizing blood glucose after acute ischemic stroke
Nina T Gentile1, Michael W Seftchick, Tien Huynh
1Temple University School of Medicine, Philadelphia, PA 19140, USA. ngentile@temple.edu
Summary
Hyperglycemia (high blood sugar) after ischemic stroke increases mortality. Achieving normal blood glucose levels within 48 hours significantly improves survival rates for stroke patients.
Area of Science:
- Neurology
- Endocrinology
- Critical Care Medicine
Background:
- Hyperglycemia following cerebral ischemia is linked to increased brain injury and poorer outcomes in stroke patients.
- Effective glycemic control is crucial for managing acute stroke and improving patient survival.
Purpose of the Study:
- To investigate the impact of initial blood glucose levels and glycemic control on mortality in patients with acute ischemic stroke.
- To determine if normalizing blood glucose levels during hospitalization improves survival rates.
Main Methods:
- A retrospective study analyzed data from patients diagnosed with ischemic stroke over a 40-month period.
- Patients were categorized based on admission blood glucose levels and glycemic control within the first 48 hours of hospitalization.
Main Results:
- Admission hyperglycemia (blood glucose ≥ 130 mg/dL) was associated with a 3.15-fold increased mortality risk.
- Persistent hyperglycemia during the first 48 hours showed an even higher mortality risk (OR = 6.54).
- Glycemic control, normalizing blood glucose to < 130 mg/dL, resulted in a 4.6-fold decrease in mortality risk and was an independent determinant of survival.
Conclusions:
- Admission hyperglycemia is a significant predictor of worse outcomes in acute ischemic stroke.
- Prompt normalization of blood glucose levels within 48 hours of hospitalization offers a substantial survival benefit for patients with thromboembolic stroke.
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