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Updated: Apr 30, 2026
06:08
Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
Published on: March 8, 2019
20.4K
Microarray Analysis of Human Abdominal Aortic Aneurysm With Emphasis on Cardiovascular Genes Revealed Differentially
Song Lu1,2, Li Ping Li1, John V White3
1Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA, U.S.A.
In Vivo (Athens, Greece)
|April 28, 2026
Summary
This study identified 35 differentially expressed genes in abdominal aortic aneurysm (AAA) lesions compared to normal aortas. Six novel genes were found to be significantly altered in AAA development.
Area of Science:
- Vascular Biology
- Genomics
- Atherosclerosis Research
Background:
- Abdominal aortic aneurysm (AAA) is a life-threatening condition characterized by aortic wall weakening.
- Understanding the molecular mechanisms underlying AAA pathogenesis is crucial for developing effective treatments.
Purpose of the Study:
- To investigate gene expression profiles in AAA lesions versus normal aortas.
- To identify novel genes associated with AAA development and progression.
Main Methods:
- Utilized cDNA microarray analysis of 588 cardiovascular-related genes.
- Validated differential gene expression using real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR).
Main Results:
- Identified 35 differentially expressed genes between AAA lesions and normal aortas (20 upregulated, 15 downregulated).
- Confirmed previously reported gene expression changes in AAA for 21 genes.
- Highlighted six novel genes (COL6A3, COL15A1, ICAM2, APOD, CIB, SERPINB6) upregulated and five (GJA1, SCNN1B, NPR1, ACTN1, PLN) downregulated in AAA.
Conclusions:
- Discovered eleven novel differentially expressed genes in AAA lesions.
- These findings contribute to a deeper understanding of AAA molecular pathology.
- The identified genes represent potential targets for future diagnostic and therapeutic strategies.
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