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Cholestasis induced by parabolan successfully treated with the molecular adsorbent recirculating system
Jacek Sein Anand1, Zygmunt Chodorowski, Adam Hajduk
1Clinic of Internal Medicine and Acute Poisonings, Medical University of Gdańsk, Ul. Debinki 7, 80-211 Gdańsk, Poland.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|January 27, 2006
Summary
A young bodybuilder experienced severe cholestasis after overdosing on trenbolone acetate. The molecular adsorbent recirculating system (MARS) effectively treated the condition, relieving symptoms and reducing bilirubin levels.
Area of Science:
- Toxicology
- Hepatology
- Pharmacology
Background:
- Anabolic-androgenic steroids (AAS), such as trenbolone acetate, are misused by athletes for performance enhancement.
- Overdose of AAS can lead to severe adverse health effects, including liver damage and cholestasis.
Observation:
- A 21-year-old male bodybuilder presented with jaundice and pruritus following trenbolone acetate overdose.
- Biochemical tests indicated significant cholestasis with serum bilirubin levels up to 65.5 mg/dl.
Findings:
- Standard medical treatments for cholestasis were ineffective in this patient.
- Treatment with the molecular adsorbent recirculating system (MARS) was initiated.
- Five MARS sessions, each 8-12 hours long and performed every second day, were administered.
- The MARS procedure was well-tolerated and led to sustained relief of pruritus.
Implications:
- MARS is a viable treatment option for severe AAS-induced cholestasis when conventional therapies fail.
- This case highlights the potential hepatotoxicity of trenbolone acetate and the need for medical monitoring in AAS users.
- Effective management of AAS-related complications can be achieved with advanced extracorporeal liver support systems.