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Updated: Aug 13, 2026
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Acetylator phenotype in Iraqi patients with allergic contact dermatitis
Rafid A Najim1, Makram Al-waizt, Rafi A M Al-Razzuqi
1University of Baghdad, Department of Pharmacology, College of Medicine, Iraq. rafidnajim@yahoo.com
Background:
Few studies have been done on acetylator status in ACD. This study determined acetylator status in Iraqi patients with allergic contact dermatitis (ACD) in comparison to a matched control group.
Patients And Methods:
The study included 35 ACD patients and 67 healthy volunteers. The ACD patients were diagnosed clinically and the diagnosis was confirmed by patch test. A detailed history wastaken from the patients. After an overnight fast, each control subject and each patient received a single oral dose of 100 mg of dapsone. A blood sample was collected after 3 hours and plasma was separated for determiination of dapsone and monoacetyldapsone by HPLC.
Results:
Twenty-six of the 35 ACD patients returned for follow up. The frequency of slow acetylators in healthy individuals was 71.6%, while the frequency of rapid acetylators was 28.4%. The frequency of slow acetylators in ACD patients was 60.0% while the frequency of rapid acetylators was 40.0%. There was no association between the acetylator status, personal history of allergy, patch-test positivity or sites of dermatitis in ACD patients.
Conclusion:
A rapid acetylator status might predispose to ACD, but does not seem to influence other features of the disease.
