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Analysis of Cell Cycle Position in Mammalian Cells
Published on: January 21, 2012
Cell cycle kinetics analysis of HeLa cells exposed to aphidicolin: computer simulation
S Y Abed1, S M elAssouli, O S Ozkul
1Department of Industrial Engineering, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Computers in Biology and Medicine
|July 1, 1992
Abstract:
A computer simulation model was developed and used to analyze the inhibitory effect of aphidicolin on the proliferation of Hela cells. Simulation results were compared with actual experimental results [Pedrali-Noy et al. (1980) Nuc. Acid Res. 8, 377] and were found to be in good agreement. Also, the simulation showed that aphidicolin caused cells to be accumulated at the G1/S boundary and that recruitment and synchrony occurred.

