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Lung function decline and outcomes in an adult population
David M Mannino1, Matthew M Reichert, Kourtney J Davis
1Division of Pulmonary and Critical Care Medicine, University of Kentucky Medical Center, 800 Rose Street, MN 614, Lexington, KY 40536, USA. dmannino@uky.edu
American Journal of Respiratory and Critical Care Medicine
|January 28, 2006
Summary
Rapid lung function decline in adults is linked to a higher risk of death and COPD hospitalizations. Key risk factors include advanced COPD stage, being Black, and current smoking.
Area of Science:
- Pulmonary Medicine
- Epidemiology
- Clinical Research
Background:
- Chronic obstructive pulmonary disease (COPD) significantly contributes to illness and death globally.
- Understanding factors influencing lung function decline is crucial for patient outcomes.
Purpose of the Study:
- To identify risk factors associated with rapid lung function decline.
- To examine the outcomes, including mortality and COPD hospitalizations, of rapid lung function decline in a US adult cohort.
Main Methods:
- Analysis of data from 15,536 adults aged 44-66 years from the Atherosclerosis Risk in Communities study.
- Utilized Cox proportional hazard models to assess the association between rapid lung function decline and subsequent mortality and COPD hospitalizations.
Main Results:
- Factors associated with not completing follow-up spirometry included Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 3 or 4 disease, being Black, and current smoking.
- Participants with GOLD stage 3 or 4 disease were more likely to experience rapid lung function decline.
- Rapid lung function decline was associated with a modestly increased risk of death (HR 1.4) and COPD-related hospitalizations (HR 1.4).
Conclusions:
- Rapid lung function decline is an independent predictor of increased mortality risk.
- A modest increase in the risk of COPD hospitalizations is associated with rapid lung function decline.
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