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Related Experiment Videos

Antioxidant vitamin C improves endothelial function in obstructive sleep apnea.

Mathias Grebe1, Hans Joachim Eisele, Norbert Weissmann

  • 1Division of Cardiology and Angiology, Department of Internal Medicine, Justus-Liebig University, Giessen, Germany. mathias.grebe@innere.med.uni-giessen.de

American Journal of Respiratory and Critical Care Medicine
|January 28, 2006
PubMed
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Obstructive sleep apnea (OSA) is linked to endothelial dysfunction, which improves with vitamin C. This suggests oxidative stress contributes to cardiovascular risks in OSA patients.

Area of Science:

  • Cardiovascular Medicine
  • Sleep Medicine
  • Oxidative Stress Research

Background:

  • Obstructive sleep apnea (OSA) is a condition linked to increased cardiovascular risks.
  • OSA is associated with endothelial dysfunction and heightened oxidative stress.
  • Endothelial dysfunction may mediate OSA's cardiovascular complications.

Purpose of the Study:

  • To investigate the link between endothelial dysfunction and oxidative stress in OSA.
  • To test if vitamin C, an antioxidant, can improve endothelial function in OSA patients.

Main Methods:

  • Flow-mediated dilation (FMD) of the brachial artery was measured using ultrasound.
  • Study included 10 untreated OSA patients and 10 healthy controls.
  • FMD was assessed before and after intravenous vitamin C administration.

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Main Results:

  • Baseline FMD was significantly lower in OSA patients compared to controls.
  • Vitamin C did not alter FMD in control subjects.
  • Vitamin C administration normalized FMD in OSA patients.

Conclusions:

  • Reduced endothelial-dependent vasodilation in OSA patients is acutely improved by vitamin C.
  • Findings support oxidative stress as a key factor in OSA-related endothelial dysfunction.
  • Antioxidant therapies warrant investigation for managing OSA-associated cardiovascular disease.