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The platelet componentof hemostasis in aortic surgery

M A Charnaia1, Iu A Morozov, V G Gladysheva

  • 1Russian Scientific Center of Surgery, RAMS, Moscow, Russia.

Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery
|January 28, 2006
PubMed

The lack of significant changes in the count and function of platelets in aortic surgery without use of cardiopulmonary bypass (CPB) confirms that factors of extracorporeal circulation exert a remarkable adverse action on the platelet component of hemostasis. In operations performed under hypothermic perfusion or circulatory arrest, disorders of the platelet component even in case of the use of 2 mln. CIU trasylol (aprotinin) are most pronounced which gives rise to excessive postoperative blood loss in the given patient group. It may be assumed that the increase of the dose of trasylol up to 6 mln. CIU will allow, owing to its cytoprotective action, preserve as well as possible the quantitative and qualitative properties of platelets.

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