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Updated: Aug 13, 2026

Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
[Neonatal infection with Listeria monocytogenes: rare, but serious]
M van Stuijvenberg1, L Spanjaard, K A Bergman
1Universitair Medisch Centrum Groningen, locatie Beatrix Kinderkliniek, afd. Neonatologie, Postbus 30.000, 9700 RB Groningen. m.van.stuijvenberg@bkk.umcg.nl
Insights
Neonatal invasive Listeria monocytogenes infection is rare but serious, with two of three infants dying. Maternal consumption of unpasteurised milk was a risk factor, highlighting the need for dietary advice during pregnancy.
Area of Science:
- Neonatal infections
- Microbiology
- Public Health
Background:
- Listeria monocytogenes is a pathogen that can cause severe invasive infections in neonates.
- Neonatal listeriosis can lead to significant morbidity and mortality.
- Understanding transmission routes and risk factors is crucial for prevention.
Observation:
- A case series identified three infants with invasive Listeria monocytogenes infection between 1993 and 2003.
- Two of the three infants died during the neonatal period.
- Maternal consumption of unpasteurised cow's milk was identified as a potential source in one fatal case.
Findings:
- The incidence of neonatal invasive listeriosis in The Netherlands is approximately 1.3 per 100,000 live births annually.
- This incidence rate has remained stable over the past two decades.
- Maternal fever preceding parturition was noted in cases of infant mortality.
Implications:
- Pregnant women should receive clear dietary advice to avoid potentially contaminated foods, such as unpasteurised dairy products.
- Continued vigilance and public health awareness regarding food safety are essential to prevent neonatal listeriosis.
- Early recognition and intensive care can improve outcomes, but prevention remains paramount due to the infection's severity.
Abstract:
Between 1993 and 2003, three infants, two girls and a boy, were found to have an invasive infection with Listeria monocytogenes. They received intensive care including respiratory and circulatory support, antibiotics, and treatment of the neurological complications when possible. One of the girls survived without sequelae but the other two infants died in the neonatal period. In one of these two cases there was a clear clue to the source of the infection in the dietary history of the mother: she had consumed unpasteurised cow's milk. The mothers ofthe infants that died had developed fever shortly before parturition. In The Netherlands, the incidence of neonatal invasive infection with Listeria is estimated at 1.3 per 100,000 live-born children per year. This figure seems not to have changed in the last 20 years. Because of the risk of this rare but serious infection, dietary advice to pregnant women to avoid possibly contaminated food is still relevant.
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