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Updated: Aug 13, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Epileptogenesis and rational therapeutic strategies
H Stefan1, F H Lopes da Silva, W Löscher
1Epilepsy Centre - Neurological Clinic, University Erlangen-Nuernberg, Erlangen, Germany. herman.stefan@neuro.imed.uni-erlangen.de
Abstract:
The understanding of neurobiological mechanisms of epileptogenesis is essential for rational approaches for a possible disease modification as well as treatment of underlying causes of the epilepsies. More effort is necessary to translate results from basic investigations into new approaches for clinical research and to better understand a relationship with findings from clinical studies. The following report is a condensed synapsis in which molecular mechanisms of epileptogenesis, pharmacological modulation of epileptogenesis, evidence based therapy, refractoriness and prediction of outcome is provided in order to stimulate further collaborative international research.
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