Related Experiment Videos
Systematic screening for Chlamydia trachomatis: estimating cost-effectiveness using dynamic modeling and Dutch data
Robin de Vries1, Jan E A M van Bergen, Lolkje T W de Jong-van den Berg
1Groningen University Institute for Drug Exploration/University of Groningen Research Institute of Pharmacy, Groningen, The Netherlands.
Summary
A one-off Chlamydia trachomatis (CT) screening program for young adults in the Netherlands is cost-effective, preventing complications for a net cost of 373 euros per major outcome averted. Screening women only is most cost-effective.
Area of Science:
- Public Health
- Epidemiology
- Health Economics
Background:
- Chlamydia trachomatis (CT) is a prevalent sexually transmitted infection among young adults.
- Effective screening programs are crucial for reducing CT-related complications and transmission.
Purpose of the Study:
- To estimate the cost-effectiveness of a one-off CT screening program with partner treatment for Dutch young adults.
- To evaluate the impact of screening on CT incidence and prevalence using a dynamic model.
Main Methods:
- A dynamic Susceptible-Infected-Susceptible (SIS) model was developed to simulate CT transmission dynamics.
- Data from a pilot study on prevalence, participation, and sexual behavior were utilized.
- A predictive decision model calculated averted complications, with cost-effectiveness expressed as net costs per major outcome averted (MOA).
Main Results:
- The screening program reduced overall CT prevalence from 1.79% to 1.05%.
- Net costs were 373 euros per MOA in the baseline analysis.
- Partner treatment and reminders improved cost-effectiveness; screening women only was more cost-effective.
Conclusions:
- The Dutch society incurs a net cost for CT complication prevention through screening young adults.
- The cost of 373 euros per MOA is considered reasonable.
- Screening women only is pharmacoeconomically favorable; the dynamic model better reflects CT's infectious nature.