Related Experiment Video
Updated: Aug 13, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Iterative one-pot syntheses of chitotetroses
Lijun Huang1, Zhen Wang, Xiaoning Li
1Department of Chemistry, The University of Toledo, 2801 W. Bancroft Street, MS 602, Toledo, OH 43606, USA.
Abstract:
Rapid syntheses of chitotetrose derivatives were achieved in good yields using the newly developed reactivity independent iterative one-pot strategy. The protective groups on donors and acceptors were independently evaluated allowing matching of the two partners in glycosylation. No anomeric reactivity adjustments or intermediate purification were necessary thus significantly improving the overall synthetic efficiency. Only near stoichiometric amounts of building blocks were required for the assembly of target molecules further highlighting the potential of the iterative one-pot method in complex oligosaccharide synthesis.
Related Concept Videos
Prochirality
Molecules with Multiple Chiral Centers
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Cycloaddition Reactions: Overview
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

