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Updated: Aug 13, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
Three rare cases of anthrax arising from the same source
Farhang Babamahmoodi1, Fereshteh Aghabarari, Abbas Arjmand
1Department of Infectious Disease, Sari School of Medicine, Mazandaran University of Medical Sciences, 48168 Sari, Iran.
Abstract:
Anthrax is an acute bacterial infection caused by Bacillus anthracis. Humans become infected under natural conditions by contact with infected animals or contaminated animal products. About 95% of human anthrax is cutaneous and 5% respiratory. Gastrointestinal anthrax is very rare, and has been reported in less than 1% of all cases. Anthrax meningitis is a rare complication of any of the other three forms of disease. We report three rare cases of anthrax (gastrointestinal, oropharyngeal and meningitis) arising from the same source. The three patients were from a single family and were admitted with different clinical pictures after the ingestion of half-cooked meat from a sick sheep. These cases emphasize the need for awareness of anthrax in the differential diagnosis in areas where the disease remains endemic.
Insights
Three family members contracted rare forms of anthrax (gastrointestinal, oropharyngeal, meningitis) after eating contaminated sheep meat. This highlights the importance of considering anthrax in endemic areas.
Area of Science:
- Infectious Diseases
- Bacteriology
- Public Health
Background:
- Anthrax is an acute bacterial infection caused by Bacillus anthracis.
- Human infection typically occurs through contact with infected animals or contaminated animal products.
- Cutaneous anthrax accounts for 95% of cases, while respiratory anthrax is 5%.
Observation:
- Gastrointestinal anthrax is rare (<1% of cases), and anthrax meningitis is a rare complication.
- Three rare cases of anthrax (gastrointestinal, oropharyngeal, and meningitis) occurred in a single family from the same source.
- Patients presented with distinct clinical symptoms after consuming undercooked meat from a sick sheep.
Findings:
- The study details three concurrent, rare presentations of anthrax within one family.
- Ingestion of contaminated meat was identified as the source of infection.
- The cases demonstrate varied clinical manifestations of Bacillus anthracis infection.
Implications:
- These cases underscore the need for heightened clinical suspicion of anthrax in endemic regions.
- Awareness of anthrax is crucial for differential diagnosis, especially with unusual presentations.
- Proper food handling and animal husbandry practices are vital for preventing anthrax transmission.
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The first classification is based on the development of the disease, and it includes the following categories:
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