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Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
Published on: April 21, 2019
Parental history of allergy, maternal serum IgE & cord serum IgE
1Institute of Science, 15, Madam Cama Road, Mumbai - 400 003, India. rescience_5@yahoo.co.in
Insights
Maternal history of allergy is linked to higher cord serum immunoglobulin E (IgE) in newborns. Cord serum IgE testing can help identify infants at risk for allergies.
Area of Science:
- Pediatric Allergy and Immunology
- Neonatal Health
- Immunology
Background:
- Allergic reactions significantly impact childhood health and well-being.
- Early identification and management of childhood allergies are crucial to prevent severe allergic conditions.
Purpose of the Study:
- To investigate the correlation between cord serum immunoglobulin E (IgE) levels and parental allergy history.
- To assess the relationship between cord serum IgE and maternal serum IgE.
Main Methods:
- A study involving 100 pregnant women in Mumbai.
- Collection of maternal and cord blood samples for total serum IgE and IgA analysis.
- Gathering of parental allergic history.
Main Results:
- A positive correlation was found between cord serum IgE and maternal serum IgE when mothers had an allergy history.
- Elevated cord serum IgE was significantly associated with maternal allergy history, but not paternal history.
- Cord serum IgA levels were low, ruling out maternal blood contamination.
Conclusions:
- Maternal history of allergic disease is associated with elevated cord serum IgE in newborns.
- Cord serum IgE is a valuable, non-invasive tool to assess neonatal allergic status, complementing maternal history.
Background:
Allergic reactions are responsible for much illness, irritation and disquiet in the life of the child. Recognition and management of allergy in childhood is of great importance to prevent major allergic syndromes.
Aim:
To correlate cord serum IgE with parental history of allergy and maternal serum IgE.
Settings And Design:
In consultation with the attending gynecologist a survey of 950 pregnant women from different parts of Mumbai, visiting gynecology clinics was carried out.
Method:
100 pregnant women were randomly recruited for the study. Allergic history of both the parents was collected. Blood samples of mothers and matched cord blood samples were collected. Total serum IgE levels were determined using solid-phase immunoradiometric assay. Total serum IgA from each cord blood sample was checked.
Observation & Results:
(1) Positive correlation was observed between cord serum IgE and matched maternal serum IgE, with mothers having history of allergy. (2) There was no relation (P=0.99) between cord serum IgE and matched maternal serum IgE, where mothers had no history of allergy. (3) A significant elevation in cord serum IgE was found only with maternal but not with paternal history of allergy. (4) No elevation was found in cord serum IgE (0.5 IU/mL). (6) All cord serum samples had IgA< 0.06 IU/mL ruling out the possibility of contamination with maternal blood.
Conclusion:
The maternal history of allergic disease is associated with an elevated cord serum IgE among newborns. Cord serum IgE is a simple, non-invasive and convenient test, which can supplement the maternal history to provide more discriminative information about the allergic status of the newborn.
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