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Updated: Oct 7, 2026

High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
Published on: July 25, 2014
EndoCyte, an interactive computer program for quantitative analysis of receptor-mediated endocytosis
A Zelić1, Z Bajzer, S Vuk-Pavlović
1Division of Developmental Oncology Research, Mayo Clinic, Rochester, MN 55905.
Abstract:
We present EndoCyte, a user friendly interactive program for quantitative analysis of receptor-mediated endocytosis. The data, comprised of time-dependent concentrations of the ligand at the cell surface and the ligand internalized by cells, are analyzed by the application of a set of nested mathematical models of endocytosis. EndoCyte reduces data to parameters conventional in description of receptor-mediated endocytosis and a parameter which describes the non-linear effects. The performance of EndoCyte is documented by the analysis of applications to synthetic data.
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