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Updated: Aug 13, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Monoamine receptors in human corneal epithelium and endothelium
Matthias Grueb1, Barbara Wallenfels-Thilo, Oliver Denk
1Department of Ophthalmology, University of Tuebingen, Tuebingen, Germany. matthias.grueb@med.uni-tuebingen.de
Purpose:
Monoamine receptors are found throughout the body. Reports about the presence of monoamine receptors in the human cornea are inconsistent.
Methods:
Immunohistochemistry, immunofluorescence and immunoblotting were used to localize monoamine receptor sites on human corneal epithelium and endothelium.
Results:
Antibodies to alpha-1, beta-1 and beta-2 adrenergic receptors and to D1-like and 5HT-7 receptors were bound in corneal epithelium. Antibodies to alpha-1, alpha-2A, beta-1 and beta-2 adrenergic receptors and to 5HT-7 receptors were bound in corneal endothelium.
Conclusions:
Our data demonstrate the presence of several monoamine receptors in the human cornea. These receptors may play a role in the regulation of fluid transport or corneal homeostasis.
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