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Updated: Jul 27, 2026
09:25
Transplantation Into the Mouse Ovarian Fat Pad
Published on: September 7, 2016
Hormonal function after ovarian transposition to the abdominal subcutaneous fat tissue
S Nagao1, K Fujiwara, H Ishikawa
1Department of Obstetrics and Gynecology, Kawasaki Medical School, 577 Matsushima, Kurashiki-City 701-0192, Japan.
Summary
Ovarian transposition to abdominal subcutaneous fat tissue (OTAFT) may impact ovarian function, particularly in younger patients. However, postmenopausal hormone levels after OTAFT are comparable to hormone replacement therapy (HRT).
Area of Science:
- Gynecology
- Reproductive Endocrinology
- Surgical Innovation
Background:
- Ovarian transposition is a technique to preserve ovarian function after hysterectomy.
- Ovarian transposition to the abdominal subcutaneous fat tissue (OTAFT) is a novel approach.
- Assessing hormonal function post-OTAFT is crucial for understanding its impact on menopause.
Purpose of the Study:
- To evaluate the hormonal function of ovaries after OTAFT.
- To compare ovarian function in patients who underwent OTAFT versus those who retained ovaries without transposition.
- To determine the menopausal status and hormone levels in different patient groups.
Main Methods:
- Retrospective study of 27 patients undergoing OTAFT (group A) and 42 patients with retained ovaries (group B) post-hysterectomy.
- Comparison with 19 patients who had hysterectomy, oophorectomy, and hormone replacement therapy (HRT) (group C).
- Serum follicle-stimulating hormone (FSH) levels monitored to determine time to menopause (FSH >40 mIU/mL twice).
Main Results:
- No significant difference in cumulative ovarian survival between OTAFT and non-transposed ovaries (P=0.10).
- Younger patients (≤40 years) showed significantly declined ovarian function after OTAFT compared to controls (P=0.04).
- Postmenopausal FSH levels in OTAFT patients were similar to HRT patients, but significantly lower than in non-transposed ovaries (P=0.002).
Conclusions:
- OTAFT may affect ovarian function, especially in younger women.
- Transposed ovaries in postmenopausal women likely secrete sufficient estrogen, comparable to HRT.
- OTAFT is a viable option for preserving some ovarian endocrine function post-hysterectomy.
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