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Reversible sirolimus-associated pneumonitis after heart transplantation
Iman M Hamour1, Taurn K Mittal, Alex D Bell
1Department of Transplantation, The Royal Brompton and Harefield NHS Trust, Harefield Hospital, Middlesex, United Kingdom.
Abstract:
Sirolimus (rapamycin) and everolimus are immunosuppressive agents that inhibit cardiac allograft vasculopathy. Sirolimus has been widely used in renal transplantation, and its use in heart transplantation is increasing. Sirolimus-associated pneumonitis has been described in renal transplant patients. Two cases of sirolimus-associated pneumonitis have been reported after cardiac transplantation. Only 1 case has been described in detail, and this had a fatal outcome. Here, we present a case of sirolimus-associated interstitial pneumonitis in a cardiac transplant recipient that resolved completely with withdrawal of the drug and treatment with corticosteroids.