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[Primary cutaneous extraskeletal Ewing's sarcoma].

M Kourda1, S Chatti, M Sfia

  • 1Service de Dermatologie, Hôpital de Nabeul, Tunisie. kourda_mouna@yahoo.fr

Annales De Dermatologie Et De Venereologie
|February 1, 2006
PubMed
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This case report details a rare cutaneous Ewing's sarcoma on a child's foot. Successful treatment with chemotherapy led to complete tumor regression, suggesting a favorable prognosis for this rare cancer.

Area of Science:

  • Pediatric Oncology
  • Dermatologic Surgery
  • Skeletal System Neoplasms

Background:

  • Cutaneous extraskeletal Ewing's sarcoma is an exceptionally rare malignancy, predominantly affecting pediatric patients.
  • This study presents a unique case of cutaneous Ewing's sarcoma occurring on the sole of a child's foot.

Observation:

  • A 9-year-old child presented with a 3-month history of a rapidly growing, painful, ulcerative skin tumor on the heel.
  • The tumor measured 3.5 cm in diameter and was crusted on the surface.
  • Histological and immunohistochemical analyses confirmed the diagnosis of Ewing's sarcoma.

Findings:

  • Diagnostic confirmation involved histological examination revealing a malignant proliferation of small round cells in the dermis.
  • Immunohistochemical staining was positive for CD99, and cytogenetic analysis identified a translocation between chromosomes 22 and 11.

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  • Staging examinations were negative, and the patient achieved complete tumor regression following polychemotherapy.
  • Implications:

    • Cutaneous Ewing's sarcoma demonstrates a more favorable prognosis compared to its bone counterpart, with lower rates of metastasis and relapse.
    • While treatment protocols are not standardized, a multimodal approach including polychemotherapy, surgery, and/or radiotherapy is typically employed.
    • This case underscores the importance of considering rare diagnoses in pediatric oncology and highlights the efficacy of chemotherapy in managing cutaneous Ewing's sarcoma.